The Flagship Pioneering spinout uses permanent bonds to target shallow pockets, drastically expanding the druggable universe for small molecules.
The discovery of a stable single-electron covalent bond between two carbon atoms validates a century-old theory. The discovery of a stable single-electron covalent bond between two carbon atoms ...
Covalent inhibitors are a specialized class of small molecules designed to form chemical bonds with their target proteins, often resulting in prolonged target engagement and enhanced potency. The ...
Novartis is serving up $60 million to partner with Matchpoint Therapeutics in hopes of getting an oral covalent inhibitor over the line for inflammatory diseases that have been historically difficult ...
Numerous applications of phenolic compounds, a large family of naturally occurring molecules, in biosensing, bioimaging, and disease treatment can not be ...
Chemists at Hokkaido University have experimentally confirmed the existence of a single-electron carbon-carbon bond for the first time (Nature 2024, DOI: 10.1038/s41586-024-07965-1). Linus Pauling ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results