Deep-learning algorithms enhance mutation detection in cancer and RNA sequencing

Researchers from the Faculty of Engineering at The University of Hong Kong (HKU) have developed two innovative deep-learning algorithms, ClairS-TO and Clair3-RNA, that significantly advance genetic ...
ascopubs.org

EGFR Mutation Detection in Brazilian Patients With Non–Small-Cell Lung Cancer: Lessons From Real-World Data Scenario of Molecular Testing

Trends in Lung Cancer Incidence and Mortality (1990-2019) in the United States: A Comprehensive Analysis of Gender and State-Level Disparities A total of 7,413 tumor specimens were tested. The ...
Nanowerk

Uniting DNA origami and CRISPR to enhance detection of genetic mutations in cancer diagnostics

Against this backdrop, a team led by Professor Zhang Han and Associate Professor Chen Zhi from Shenzhen University in China , has demonstrated an innovative approach that combines DNA origami, CRISPR ...
News Medical

Highly sensitive CRISPR-based method designed to detect low-frequency cancer mutations

Liquid biopsy is increasingly recognized as a promising tool for cancer detection and treatment monitoring, yet its effectiveness is often limited by the extremely low levels of tumor-derived DNA ...
ascopubs.org

Novel Clinical Tool to Estimate Risk of False-Negative KRAS Mutations in Circulating Tumor DNA Testing

The model suggests that negative KRAS findings are believable when the maximum of APC and TP53 frequencies is at least 8% (corresponding posterior probability of false negative <5%). Validation ...
News Medical

Machine learning enhances early detection of glioma mutations

This is shown by a recent study by Karl Landsteiner University of Health Sciences (KL Krems). In this study, data from physio-metabolic magnetic resonance images were analyzed to identify mutations in ...
EurekAlert!

Mutation detection of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha for treatment guidance in breast cancer

Breast cancer remains a significant health concern worldwide, with diverse molecular subtypes that necessitate personalized therapeutic approaches. Recent advances have highlighted the importance of ...
Drinks

Carlsberg gets grant for method of identifying organisms with predetermined mutations in target sequences

Carlsberg has patented a method using digital PCR to identify specific nucleotide mutations in mutated genes. The process involves mutagenizing a pool of organisms, dividing them into sub-pools, and ...