Activated phosphoinositide 3‐kinase delta syndrome (APDS) represents a rare primary immunodeficiency that arises from gain‐of‐function mutations in genes encoding key components of the PI3Kδ complex, ...
This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive ...
Phosphoinositide signaling pathways have been implicated in the metabolic alterations associated with various human diseases, including breast cancer. The phosphatidylinositol-5-phosphate 4-kinase ...
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